Steroid Hormone Receptors in Prostate Cancer: A Hard Habit to Break?

被引：210

作者：

Attard, Gerhardt ^{[1
,2
]}

Cooper, Colin S. ^{[1
]}

de Bono, Johann S. ^{[1
,2
]}

机构：

[1] Inst Canc Res, Sutton SM2 5PT, Surrey, England

[2] Royal Marsden Hosp, Sutton SM2 5PT, Surrey, England

来源：

CANCER CELL | 2009年 / 16卷 / 06期

基金：

英国医学研究理事会;

关键词：

MUTATED ANDROGEN RECEPTOR; LEUKEMIA GROUP-B; ANTIANDROGEN WITHDRAWAL; TRANSCRIPTION FACTOR; ABIRATERONE ACETATE; ADRENAL ANDROGENS; GROWTH-FACTOR; CELL-GROWTH; OPEN-LABEL; PHASE-II;

D O I：

10.1016/j.ccr.2009.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical data from abiraterone acetate and MDV-3100 confirm continued androgen receptor (AR) addiction in a significant proportion of castration-resistant prostate cancers (CRPC). However, patients nearly invariably progress with a rise in prostate-specific antigen, suggesting resumption of transcription of hormone-regulated genes. If CRPC remains addicted to steroid receptor signaling, including, but not exclusive, to AR, how does reactivation occur? Or if cancers lose this addiction, do they remain driven by the same oncogenic mechanisms? The future development of therapeutics for CRPC should be informed by an understanding of the mechanisms underlying disease progression following treatment with these novel agents.

引用

页码：458 / 462

页数：5

共 51 条

[1] Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer [J].

Attard, G. ;

Clark, J. ;

Ambroisine, L. ;

Mills, I. G. ;

Fisher, G. ;

Flohr, P. ;

Reid, A. ;

Edwards, S. ;

Kovacs, G. ;

Berney, D. ;

Foster, C. ;

Massie, C. E. ;

Fletcher, A. ;

De Bono, J. S. ;

Scardino, P. ;

Cuzick, J. ;

Cooper, C. S. .

BRITISH JOURNAL OF CANCER, 2008, 99 (02) :314-320

[2] Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven [J].

Attard, Gerhardt ;

Reid, Alison H. M. ;

Yap, Timothy A. ;

Raynaud, Florence ;

Dowsett, Mitch ;

Settatree, Sarah ;

Barrett, Mary ;

Parker, Christopher ;

Martins, Vanessa ;

Folkerd, Elizabeth ;

Clark, Jeremy ;

Cooper, Colin S. ;

Kaye, Stan B. ;

Dearnaley, David ;

Lee, Gloria ;

de Bono, Johann S. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) :4563-4571

[3] Selective Inhibition of CYP17 With Abiraterone Acetate Is Highly Active in the Treatment of Castration-Resistant Prostate Cancer [J].

Attard, Gerhardt ;

Reid, Alison H. M. ;

A'Hern, Roger ;

Parker, Christopher ;

Oommen, Nikhil Babu ;

Folkerd, Elizabeth ;

Messiou, Christina ;

Molife, L. Rhoda ;

Maier, Gal ;

Thompson, Emilda ;

Olmos, David ;

Sinha, Rajesh ;

Lee, Gloria ;

Dowsett, Mitch ;

Kaye, Stan B. ;

Dearnaley, David ;

Kheoh, Thian ;

Molina, Arturo ;

de Bono, Johann S. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (23) :3742-3748

[4] Antitumor Activity with CYP17 Blockade Indicates That Castration-Resistant Prostate Cancer Frequently Remains Hormone Driven [J].

Attard, Gerhardt ;

Reid, Alison H. M. ;

Olmos, David ;

de Bono, Johann S. .

CANCER RESEARCH, 2009, 69 (12) :4937-4940

[5] Characterization of ERG, AR and PTEN Gene Status in Circulating Tumor Cells from Patients with Castration-Resistant Prostate Cancer [J].

Attard, Gerhardt ;

Swermenhuis, Joost F. ;

Olmos, David ;

Reid, Alison H. M. ;

Vickers, Elaine ;

A'Hern, Roger ;

Levink, Rianne ;

Coumans, Frank ;

Moreira, Joana ;

Riisnaes, Ruth ;

Oommen, Nikhil Babu ;

Hawche, George ;

Jameson, Charles ;

Thompson, Emilda ;

Sipkema, Ronald ;

Carden, Craig P. ;

Parker, Christopher ;

Dearnaley, David ;

Kaye, Stan B. ;

Cooper, Colin S. ;

Molina, Arturo ;

Cox, Michael E. ;

Terstappen, Leon W. M. M. ;

de Bono, Johann S. .

CANCER RESEARCH, 2009, 69 (07) :2912-2918

[6] BRAF and NRAS mutations in melanoma:: potential relationships to clinical response to HSP90 inhibitors [J].

Banerji, Udai ;

Affolter, Annette ;

Judson, Ian ;

Marais, Richard ;

Workman, Paul .

MOLECULAR CANCER THERAPEUTICS, 2008, 7 (04) :737-739

[7]

Bubendorf L, 1999, CANCER RES, V59, P803

[8]

Buchanan G, 2001, CLIN CANCER RES, V7, P1273

[9] Reactivation of Androgen Receptor-Regulated TMPRSS2:ERG Gfene Expression in Castration-Resistant Prostate Cancer [J].

Cai, Changmeng ;

Wang, Hongyun ;

Xu, Youyuan ;

Chen, Shaoyong ;

Balk, Steven P. .

CANCER RESEARCH, 2009, 69 (15) :6027-6032

[10] Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancer [J].

Cano, Patricia ;

Godoy, Alejandro ;

Escamilla, Rosalba ;

Dhir, Rajiv ;

Onate, Sergio A. .

CANCER RESEARCH, 2007, 67 (02) :511-519

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