Identification of TOR signaling complexes: more TORC for the cell growth engine

被引：125

作者：

Abraham, RT ^{[1
]}

机构：

[1] Burnham Inst, Ctr Canc Res, Program Signal Transduct Res, La Jolla, CA 92037 USA

来源：

CELL | 2002年 / 111卷 / 01期

关键词：

D O I：

10.1016/S0092-8674(02)01009-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Target of Rapamycin (TOR) proteins function in signaling pathways that promote protein synthesis and cell growth. In yeast, TOR signaling is regulated by nutrient availability, whereas in metazoan cells TOR activities may be controlled by both nutrients and growth factors. The recent identification of novel TOR-interacting proteins has provided crucial insights into TOR regulation and function.

引用

页码：9 / 12

页数：4

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