Apolipoprotein E and atherosclerosis

被引：192

作者：

Curtiss, LK

Boisvert, WA

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 2000年 / 11卷 / 03期

关键词：

D O I：

10.1097/00041433-200006000-00004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease. Curr Opin Lipidol 11:243-251. (C) 2000 Lippincott Williams & Wilkins.

引用

收藏

页码：243 / 251

页数：9

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