Vaccines for the prevention of cardiovascular disease

被引：16

作者：

Ryan, Una S. ^{[1
]}

Rittershaus, Charles W. ^{[1
]}

机构：

[1] AVANT Immunotherapeut Inc, Needham, MA 02494 USA

来源：

VASCULAR PHARMACOLOGY | 2006年 / 45卷 / 05期

关键词：

cardiovascular disease; HDL; CVD; CETP;

D O I：

10.1016/j.vph.2006.08.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atherosclerosis, especially coronary heart disease (CHD), remains a most significant global public health problem. Highly effective LDL-lowering therapies have gained widespread adoption in the United States and throughout the developed world, but therapeutic options for raising low HDL, a key independent risk factor for CHD, remain limited. We are developing a vaccine approach to raising HDL, by inducing an immune response to endogenous cholesteryl ester transfer protein (CETP), and have demonstrated proof of principle in preclinical and clinical models. This vaccine approach may offer the opportunity to address low HDL with a cost-effective semi-annual injection. Published by Elsevier Inc.

引用

收藏

页码：253 / 257

页数：5

相关论文

共 22 条

[1] Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from β-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide [J].

Agadjanyan, MG ;

Ghochikyan, A ;

Petrushina, I ;

Vasilevko, V ;

Movsesyan, N ;

Mkrtichyan, M ;

Saing, T ;

Cribbs, DH .

JOURNAL OF IMMUNOLOGY, 2005, 174 (03) :1580-1586

[2] Immunization with cholesterol-rich liposomes induces anti-cholesterol antibodies and reduces diet-induced hypercholesterolemia and plaque formation [J].

Alving, CR ;

Swartz, GM ;

Wassef, NM ;

Ribas, JL ;

Herderick, EE ;

Virmani, R ;

Kolodgie, FD ;

Matyas, GR ;

Cornhill, JF .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1996, 127 (01) :40-49

[3]

[Anonymous], 2004, HEART DIS STROK STAT

[4] CHOLESTEROL VACCINES [J].

BAILEY, JM .

SCIENCE, 1994, 264 (5162) :1067-1068

[5] Cholesteryl ester transfer protein - A novel target for raising HDL and inhibiting atherosclerosis [J].

Barter, PJ ;

Brewer, HB ;

Chapman, MJ ;

Hennekens, CH ;

Rader, DJ ;

Tall, AR .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (02) :160-167

[6] Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion [J].

Brousseau, ME ;

Diffenderfer, MR ;

Millar, JS ;

Nartsupha, C ;

Asztalos, BF ;

Welty, FK ;

Wolfe, ML ;

Rudling, M ;

Björkhem, I ;

Angelin, B ;

Mancuso, JP ;

Digenio, AG ;

Rader, DJ ;

Schaefer, EJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (05) :1057-1064

[7] Dibenzodioxocinones -: A new class of CETP inhibitors [J].

Brückner, D ;

Hafner, FT ;

Li, V ;

Schmeck, C ;

Telser, J ;

Vakalopoulos, A ;

Wirtz, G .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (15) :3611-3614

[8] The safety and immunogenicity of a CETP vaccine in healthy adults [J].

Davidson, MH ;

Maki, K ;

Umporowicz, D ;

Wheeler, A ;

Rittershaus, C ;

Ryan, U .

ATHEROSCLEROSIS, 2003, 169 (01) :113-120

[9] Current drug options for raising HDL cholesterol [J].

Dunbar R.L. ;

Rader D.J. .

Current Treatment Options in Cardiovascular Medicine, 2005, 7 (1) :15-23

[10] Inhibition of atherosclerosis in ApoE-null mice by immunization with ApoB-100 peptide sequences [J].

Fredrikson, GN ;

Söderberg, I ;

Lindholm, M ;

Dimayuga, P ;

Chyu, KY ;

Shah, PK ;

Nilsson, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (05) :879-884