Lipoprotein lipase: genetics, lipid uptake, and regulation

被引：424

作者：

Merkel, M

Eckel, RH

Goldberg, IJ ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA

[2] Univ Hamburg, Dept Med, Hamburg, Germany

[3] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA

来源：

JOURNAL OF LIPID RESEARCH | 2002年 / 43卷 / 12期

关键词：

triglycerides; chylomicronemia; atherosclerosis; lipoproteins; lipid metabolism; mutations; human; promoter; review;

D O I：

10.1194/jlr.R200015-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.

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页码：1997 / 2006

页数：10

相关论文

共 113 条

[1] MECHANISM OF HYPERTRIGLYCERIDEMIA IN HUMAN APOLIPOPROTEIN-(APO)-CIII TRANSGENIC MICE - DIMINISHED VERY LOW-DENSITY-LIPOPROTEIN FRACTIONAL CATABOLIC RATE ASSOCIATED WITH INCREASED APO-CIII AND REDUCED APO-E ON THE PARTICLES [J].

AALTOSETALA, K ;

FISHER, EA ;

CHEN, XL ;

CHAJEKSHAUL, T ;

HAYEK, T ;

ZECHNER, R ;

WALSH, A ;

RAMAKRISHNAN, R ;

GINSBERG, HN ;

BRESLOW, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (05) :1889-1900

[2] Fatty acids regulate the expression of lipoprotein lipase gene and activity in preadipose and adipose cells [J].

Amri, EZ ;

Teboul, L ;

Vannier, C ;

Grimaldi, PA ;

Ailhaud, G .

BIOCHEMICAL JOURNAL, 1996, 314 :541-546

[3] BETA-ADRENERGIC-CYCLIC AMP SIGNALING PATHWAY MODULATES CELL-FUNCTION AT THE TRANSCRIPTIONAL LEVEL IN 3T3-F442A ADIPOCYTES [J].

ANTRAS, J ;

LASNIER, F ;

PAIRAULT, J .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1991, 82 (2-3) :183-190

[4] Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo [J].

Babaev, VR ;

Fazio, S ;

Gleaves, LA ;

Carter, KJ ;

Semenkovich, CF ;

Linton, MF .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (12) :1697-1705

[5]

Baum L, 1999, AM J MED GENET, V88, P136, DOI 10.1002/(SICI)1096-8628(19990416)88:2<136::AID-AJMG8>3.0.CO

[6]

2-D

[7] Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene [J].

Benlian, P ;

DeGennes, JL ;

Foubert, L ;

Zhang, HF ;

Gagne, SE ;

Hayden, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (12) :848-854

[8]

BESSESEN DH, 1993, J LIPID RES, V34, P229

[9] Cloning, sequencing and structural analysis of 976 base pairs of the promoter sequence for the rat lipoprotein lipase gene.: Comparison with the mouse and human sequences [J].

Bey, L ;

Etienne, J ;

Tse, C ;

Brault, D ;

Noé, L ;

Raisonnier, A ;

Arnault, F ;

Hamilton, MT ;

Galibert, F .

GENE, 1998, 209 (1-2) :31-38

[10]

BLANCHETTEMACKIE EJ, 1989, AM J PHYSIOL, V256, pE817

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