Serum Uric Acid Is Associated With Coronary Artery Calcification

被引：32

作者：

Grossman, Chagai ^{[1
]}

Shemesh, Joseph ^{[2
]}

Koren-Morag, Nira ^{[3
]}

Bornstein, Gil ^{[4
,5
]}

Ben-Zvi, Ilan ^{[6
,7
]}

Grossman, Ehud ^{[4
,5
]}

机构：

[1] Chaim Sheba Med Ctr, Rheumatol Unit, IL-52621 Tel Hashomer, Israel

[2] Chaim Sheba Med Ctr, Cardiac Rehabil Inst, Grace Ballas Res Unit, IL-52621 Tel Hashomer, Israel

[3] Tel Aviv Univ, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel

[4] Chaim Sheba Med Ctr, Dept Internal Med D, IL-52621 Tel Hashomer, Israel

[5] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel

[6] Chaim Sheba Med Ctr, Dept Internal Med F, IL-52621 Tel Hashomer, Israel

[7] Chaim Sheba Med Ctr, Rheumatol Unit, IL-52621 Tel Hashomer, Israel

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2014年 / 16卷 / 06期

关键词：

ALL-CAUSE MORTALITY; ELECTRON-BEAM TOMOGRAPHY; HEART-DISEASE EVENTS; COMPUTED-TOMOGRAPHY; CARDIOVASCULAR RISK; METABOLIC SYNDROME; CALCIUM SCORE; HYPERTENSIVE PATIENTS; RENAL-DISEASE; FOLLOW-UP;

D O I：

10.1111/jch.12313

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Uric acid (UA) is associated with atherosclerosis, and coronary artery calcium (CAC) is a marker of atherosclerosis. The authors studied the association between UA and CAC. A total of 663 asymptomatic patients (564 men; mean age, 55 +/- 7years) were evaluated for the presence of CAC. The study population was divided into three tertiles according to their UA levels, and the prevalence of CAC was compared between the tertiles. CAC was detected in 349 (53%) patients. Levels of UA were significantly higher in those with CAC than in those without CAC (5.6+1.2 vs 5.3+1.3; P=.003). The odds ratio for the presence of CAC in the highest vs lowest UA tertile was 1.72 (95% confidence interval, 1.17-2.51). The highest UA tertile remained associated with the presence of CAC after adjustment for known cardiovascular risk factors. The results show that high serum UA levels are associated with the presence of CAC.

引用

页码：424 / 428

页数：5

共 37 条

[1] Serum uric acid and cardiovascular events in successfully treated hypertensive patients [J].

Alderman, MH ;

Cohen, H ;

Madhavan, S ;

Kivlighn, S .

HYPERTENSION, 1999, 34 (01) :144-150

[2] Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study [J].

Atar, Asli Inci ;

Yilmaz, Omer Caglar ;

Akin, Kayihan ;

Selcoki, Yusuf ;

Er, Okan ;

Eryonucu, Beyhan .

ANATOLIAN JOURNAL OF CARDIOLOGY, 2013, 13 (02) :139-145

[3] Comparison of electron beam computed tomography with intracoronary ultrasound and coronary angiography for detection of coronary atherosclerosis [J].

Baumgart, D ;

Schmermund, A ;

Goerge, G ;

Haude, M ;

Ge, JB ;

Adamzik, M ;

Sehnert, C ;

Altmaier, K ;

Groenemeyer, D ;

Seibel, R ;

Erbel, R .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 30 (01) :57-64

[4] Absence of Coronary Artery Calcification and All-Cause Mortality [J].

Blaha, Michael ;

Budoff, Matthew J. ;

Shaw, Leslee J. ;

Khosa, Faisal ;

Rumberger, John A. ;

Berman, Daniel ;

Callister, Tracy ;

Raggi, Paolo ;

Blumenthal, Roger S. ;

Nasir, Khurram .

JACC-CARDIOVASCULAR IMAGING, 2009, 2 (06) :692-700

[5] Measurement of coronary artery calcium with dual-slice helical CT compared with coronary angiography: Evaluation of CT scoring methods, interobserver variations, and reproducibility [J].

Broderick, LS ;

Shemesh, J ;

Wilensky, RL ;

Eckert, GJ ;

Zhou, XH ;

Torres, WE ;

Balk, MA ;

Rogers, WJ ;

Conces, DJ ;

Kopecky, KK .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1996, 167 (02) :439-444

[6] Long-term prognosis associated with coronary calcification - Observations from a registry of 25,253 patients [J].

Budoff, Matthew J. ;

Shaw, Leslee J. ;

Liu, Sandy T. ;

Weinstein, Steven R. ;

Mosler, Tristen P. ;

Tseng, Philip H. ;

Flores, Ferdinand R. ;

Callister, Tracy Q. ;

Raggi, Paolo ;

Berman, Daniel S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (18) :1860-1870

[7] Endothelial activation in monosodium urate monohydrate crystal-induced inflammation - In vitro and in vivo studies on the roles of tumor necrosis factor alpha and interleukin-1 [J].

Chapman, PT ;

Yarwood, H ;

Harrison, AA ;

Stocker, CJ ;

Jamar, F ;

Gundel, RH ;

Peters, AM ;

Haskard, DO .

ARTHRITIS AND RHEUMATISM, 1997, 40 (05) :955-965

[8] Coronary artery calcium score, risk factors, and incident coronary heart disease events [J].

Church, Timothy S. ;

Levine, Benjamin D. ;

McGuire, Darren K. ;

LaMonte, Michael J. ;

FitzGerald, Shannon J. ;

Cheng, Yiling J. ;

Kimball, Thomas E. ;

Blair, Steven N. ;

Gibbons, Larry W. ;

Nichaman, Milton Z. .

ATHEROSCLEROSIS, 2007, 190 (01) :224-231

[9] Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis [J].

Coutinho, Thais de A. ;

Turner, Stephen T. ;

Peyser, Patricia A. ;

Bielak, Lawrence F. ;

Sheedy, Patrick F., II ;

Kullo, Iftikhar J. .

AMERICAN JOURNAL OF HYPERTENSION, 2007, 20 (01) :83-89

[10] Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study [J].

Culleton, BF ;

Larson, MG ;

Kannel, WB ;

Levy, D .

ANNALS OF INTERNAL MEDICINE, 1999, 131 (01) :7-+

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