Thrombin receptor (protease activated receptor-1) antagonists as potent antithrombotic agents with strong antiplatelet effects

被引:81
作者
Chackalamannil, Samuel [1 ]
机构
[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
关键词
D O I
10.1021/jm0603670
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:5389 / 5403
页数:15
相关论文
共 193 条
[1]   Clinical potential of oral direct thrombin inhibitors in the prevention and treatment of venous thromboembolism [J].
Agnelli, G .
DRUGS, 2004, 64 (Suppl 1) :47-52
[2]  
Ahn HS, 2001, DRUG FUTURE, V26, P1065
[3]   Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists [J].
Ahn, HS ;
Arik, L ;
Boykow, G ;
Burnett, DA ;
Caplen, MA ;
Czarniecki, M ;
Domalski, MS ;
Foster, C ;
Manna, M ;
Stamford, AW ;
Wu, YS .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (14) :2073-2078
[4]   Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist [J].
Ahn, HS ;
Foster, C ;
Boykow, G ;
Stamford, A ;
Manna, M ;
Graziano, M .
BIOCHEMICAL PHARMACOLOGY, 2000, 60 (10) :1425-1434
[5]   DETECTION OF FUNCTIONAL RECEPTORS FOR THE PROTEINASE-ACTIVATED-RECEPTOR-2-ACTIVATING POLYPEPTIDE, SLIGRL-NH2, IN RAT VASCULAR AND GASTRIC SMOOTH-MUSCLE [J].
ALANI, B ;
SAIFEDDINE, M ;
HOLLENBERG, MD .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1995, 73 (08) :1203-1207
[7]  
ALLAROUDI WA, 2005, CURR HEMATOL REP, V4, P397
[8]   Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor [J].
Andrade-Gordon, P ;
Mayanoff, BE ;
Derian, CK ;
Zhang, HC ;
Addo, MF ;
Darrow, AL ;
Eckardt, AJ ;
Hoekstra, WJ ;
McComsey, DF ;
Oksenberg, D ;
Reynolds, EE ;
Santulli, RJ ;
Scarborough, RM ;
Smith, CE ;
White, KB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12257-12262
[9]  
[Anonymous], 2004, ATLAS HEART DIS STRO
[10]  
[Anonymous], 1990, CHOLESTEROL ATHEROSC