Extracellular superoxide dismutase and cardiovascular disease

被引：242

作者：

Fukai, T

Folz, RJ

Landmesser, U

Harrison, DG

机构：

[1] Emory Univ, Div Cardiol, Dept Med, Atlanta, GA 30322 USA

[2] Duke Univ, Med Ctr, Div Pulm & Critical Care Med, Dept Med, Durham, NC 27710 USA

来源：

CARDIOVASCULAR RESEARCH | 2002年 / 55卷 / 02期

关键词：

atherosclerosis; endothelial function; free radicals; hypertension; ischemia; nitric oxide; reperfusion;

D O I：

10.1016/S0008-6363(02)00328-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O-2(.-)), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O-2(.-) are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：239 / 249

页数：11

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[1] VASCULAR BOUND RECOMBINANT EXTRACELLULAR SUPEROXIDE-DISMUTASE TYPE-C PROTECTS AGAINST THE DETRIMENTAL EFFECTS OF SUPEROXIDE RADICALS ON ENDOTHELIUM-DEPENDENT ARTERIAL RELAXATION [J].