Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils

We investigated whether or not a combination of the selective thrombin inhibitor, argatroban. and the free radical scavenger. edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil. Argatroban or edaravone alone significantly increased postischemic cerebral blood flow and attenuated brain edema after reperfusion. However, only the combination increased the survival ratio (P < 0.05 by Mantel-Cox) and protected the damage of neuronal cells. The present study indicates that anticoagulants and free radical scavengers reciprocally function to inhibit the progression of ischemic cell damage and that a combination of these types of drugs will help to improve the outcomes after cerebral ischernia. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.