The immune response in atherosclerosis: a double-edged sword

被引：1775

作者：

Hansson, Goran K.

Libby, Peter ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Leducq Transatlantic Network Excellence Cardiovas, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Ctr Mol Med, SE-17176 Stockholm, Sweden

[4] Brigham & Womens Hosp, Donald W Reynolds Cardiovasc Clin Res Ctr, Dept Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1882

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune responses participate in every phase of atherosclerosis. There is increasing evidence that both adaptive and innate immunity tightly regulate atherogenesis. Although improved treatment of hyperlipidaemia reduces the risk for cardiac and cerebral complications of atherosclerosis, these remain among the most prevalent of diseases and will probably become the most common cause of death globally within 15 years. This Review focuses on the role of immune mechanisms in the formation and activation of atherosclerotic plaques, and also includes a discussion of the use of inflammatory markers for predicting cardiovascular events. We also outline possible future targets for prevention, diagnosis and treatment of atherosclerosis.

引用

收藏

页码：508 / 519

页数：12

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