Thymosin beta 15: A novel regulator of tumor cell motility upregulated in metastatic prostate cancer

被引：134

作者：

Bao, LR

Loda, M

Janmey, PA

Stewart, R

AnandApte, B

Zetter, BR

机构：

[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT SURG & CELL BIOL,BOSTON,MA 02115

[2] HARVARD UNIV,DEACONESS HOSP,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[3] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV EXPT MED,BOSTON,MA 02115

来源：

NATURE MEDICINE | 1996年 / 2卷 / 12期

关键词：

D O I：

10.1038/nm1296-1322

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfection of antisense thymosin beta 15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin beta 15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin beta 15 may represent a potential new biochemical marker for human prostate cancer progression.

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页码：1322 / 1328

页数：7

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