Integrins in cancer: biological implications and therapeutic opportunities

被引：2879

作者：

Desgrosellier, Jay S. ^{[1
]}

Cheresh, David A. ^{[1
]}

机构：

[1] Moores Univ Calif San Diego, Ctr Canc, Dept Pathol, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR RECEPTOR; HUMAN BREAST-CANCER; HUMANIZED MONOCLONAL-ANTIBODY; FOCAL ADHESION KINASE; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-CELL DISSEMINATION; CXCR4 CHEMOKINE RECEPTOR; ALPHA-V; ALPHA(V)BETA(3) INTEGRIN; PHASE-I;

D O I：

10.1038/nrc2748

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions crucial to the initiation, progression and metastasis of solid tumours. The importance of integrins in several cell types that affect tumour progression has made them an appealing target for cancer therapy. Integrin antagonists, including the alpha v beta 3 and alpha v beta 5 inhibitor cilengitide, have shown encouraging activity in Phase II clinical trials and cilengitide is currently being tested in a Phase III trial in patients with glioblastoma. These exciting clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.

引用

页码：9 / 22

页数：14

共 191 条

[1]

Adachi M, 2000, CLIN CANCER RES, V6, P96

[2] Role of Raf in vascular protection from distinct apoptotic stimuli [J].

Alavi, A ;

Hood, JD ;

Frausto, R ;

Stupack, DG ;

Cheresh, DA .

SCIENCE, 2003, 301 (5629) :94-96

[3]

ALBELDA SM, 1990, CANCER RES, V50, P6757

[4] Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells [J].

Aoudjit, F ;

Vuori, K .

ONCOGENE, 2001, 20 (36) :4995-5004

[5] Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-Flip and implications for anoikis [J].

Aoudjit, F ;

Vuori, K .

JOURNAL OF CELL BIOLOGY, 2001, 152 (03) :633-643

[6] Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation [J].

Asselin-Labat, Marie-Liesse ;

Sutherland, Kate D. ;

Barker, Holly ;

Thomas, Richard ;

Shackleton, Mark ;

Forrest, Natasha C. ;

Hartley, Lynne ;

Robb, Lorraine ;

Grosveld, Frank G. ;

van der Wees, Jacqueline ;

Lindeman, Geoffrey J. ;

Visvader, Jane E. .

NATURE CELL BIOLOGY, 2007, 9 (02) :201-U103

[7] Growth control by intracellular tension and extracellular stiffness [J].

Assoian, Richard K. ;

Klein, Eric A. .

TRENDS IN CELL BIOLOGY, 2008, 18 (07) :347-352

[8] Integrins in angiogenesis and lymphangiogenesis [J].

Avraamides, Christie J. ;

Garmy-Susini, Barbara ;

Varner, Judith A. .

NATURE REVIEWS CANCER, 2008, 8 (08) :604-617

[9] SIGNAL TRANSDUCTION FOR CHEMOTAXIS AND HAPTOTAXIS BY MATRIX MOLECULES IN TUMOR-CELLS [J].

AZNAVOORIAN, S ;

STRACKE, ML ;

KRUTZSCH, H ;

SCHIFFMANN, E ;

LIOTTA, LA .

JOURNAL OF CELL BIOLOGY, 1990, 110 (04) :1427-1438

[10] Integrin scintimammography using a dedicated breast imaging, solid-state γ-camera and 99mTc-labelled NC100692 [J].

Bach-Gansmo, Tore ;

Bogsrud, Trond V. ;

Skretting, Arne .

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, 2008, 28 (04) :235-239

← 1 2 3 4 5 6 7 8 9 10 →