The effects of nitric oxide synthase inhibitor, L-NAME on no production during focal cerebral ischemia in rats: Could L-NAME be the future treatment of sudden deafness?

被引:13
作者
Balkan, E
Balkan, S
Ozben, T
Serteser, M
Gumuslu, S
Oguz, N
机构
[1] AKDENIZ UNIV, FAC MED, DEPT NEUROL, ANTALYA, TURKEY
[2] AKDENIZ UNIV, FAC MED, DEPT BIOCHEM, ANTALYA, TURKEY
[3] AKDENIZ UNIV, FAC MED, DEPT ANAT, ANTALYA, TURKEY
关键词
focal cerebral ischemia; stroke; nitrite; cGMP; L-NAME; sudden deafness;
D O I
10.3109/00207459708988465
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent evidence in primary neuronal cell culture implicates NO as a mediator of glutamatergic neurotoxicity acting via N-methyl-D-aspartate (NMDA) receptors. In this study, we investigated the effects of inhibition of NOsynthase activity in focal cerebral ischemia in rats. Focal cerebral ischemia was produced by permanent occlusion of right MCA in urethane anesthetized rats. A number of indicators of brain NO production, nitrite and cGMP were determined in ipsilateral and contralateral cerebral cortex and cerebellum after 0, 10 and 60 minutes of focal cerebral ischemia. The same parameters were measured in rats pre- and posttreated with the potent Nitric oxide synthase (NOS) inhibitor, NW-nitro-L-arginine methyl ester (L-NAME).
引用
收藏
页码:61 / 77
页数:17
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