α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans

被引：217

作者：

Heusch, G

Baumgart, D

Camici, P

Chilian, W

Gregorini, L

Hess, O

Indolfi, C

Rimoldi, O

机构：

[1] Univ Essen Gesamthsch Klinikum, Abt Pathophysiol, Zentrum Innere Med, D-45122 Essen, Germany

[2] Univ Essen Gesamthsch Klinikum, Abt Kardiol, D-45122 Essen, Germany

[3] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Cyclotron Unit,Sch Med, London W12 0HS, England

[4] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[5] Osped Maggiore, Ctr Fisiol Clin, IRCCS, Milan, Italy

[6] Univ Spital Bern, Bern, Switzerland

[7] Univ Naples Federico II, Cattedra Cardiol, Naples, Italy

来源：

CIRCULATION | 2000年 / 101卷 / 06期

关键词：

coronary disease; ischemia; microcirculation; nervous system; receptors; adrenergic; alpha;

D O I：

10.1161/01.CIR.101.6.689

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of alpha-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of alpha-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to alpha-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both alpha(1)- and alpha(2)-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented alpha-adrenergic corollary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of alpha(2)-adrenergic coronary constriction.

引用

页码：689 / 694

页数：6

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