Aquaporins and glycerol metabolism

被引：114

作者：

Hibuse, Toshiyuki ^{[1
]}

Maeda, Norikazu ^{[1
]}

Nagasawa, Azumi ^{[1
]}

Funahashi, Tohru ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 08期

关键词：

aquaporin; adipocyte; glycerol; gluconeogenesis; obesity; lipolysis;

D O I：

10.1016/j.bbamem.2006.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. So far, 13 AQPs have been identified in human. AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water. Many investigators have demonstrated that AQPs play a crucial role in maintaining water homeostasis, but the physiological significance of some AQPs as a glycerol channel is not fully understood. Adipose tissue is a major source of glycerol and glycerol is one of substrates for gluconeogenesis. This review focuses on recent studies of glycerol metabolism through aquaglyceroporins, and briefly discusses the importance of glycerol channel in adipose tissues and liver. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1004 / 1011

页数：8

共 53 条

[1] Aquaporin water channels - from atomic structure to clinical medicine [J].

Agre, P ;

King, LS ;

Yasui, M ;

Guggino, WB ;

Ottersen, OP ;

Fujiyoshi, Y ;

Engel, A ;

Nielsen, S .

JOURNAL OF PHYSIOLOGY-LONDON, 2002, 542 (01) :3-16

[2] Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver [J].

Carbrey, JM ;

Gorelick-Feldman, DA ;

Kozono, D ;

Praetorius, J ;

Nielsen, S ;

Agre, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2945-2950

[3] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].

Cleeman, JI ;

Grundy, SM ;

Becker, D ;

Clark, LT ;

Cooper, RS ;

Denke, MA ;

Howard, WJ ;

Hunninghake, DB ;

Illingworth, DR ;

Luepker, RV ;

McBride, P ;

McKenney, JM ;

Pasternak, RC ;

Stone, NJ ;

Van Horn, L ;

Brewer, HB ;

Ernst, ND ;

Gordon, D ;

Levy, D ;

Rifkind, B ;

Rossouw, JE ;

Savage, P ;

Haffner, SM ;

Orloff, DG ;

Proschan, MA ;

Schwartz, JS ;

Sempos, CT ;

Shero, ST ;

Murray, EZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497

[4] Characterization of aquaporin-4 in muscle and muscular dystrophy [J].

Crosbie, RH ;

Dovico, SA ;

Flanagan, JD ;

Chamberlain, JS ;

Ownby, CL ;

Campbell, KP .

FASEB JOURNAL, 2002, 16 (09) :943-949

[5] Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain [J].

Elkjær, ML ;

Vajda, Z ;

Nejsum, LN ;

Kwon, TH ;

Jensen, UB ;

Amiry-Moghaddam, M ;

Frokiær, J ;

Nielsen, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 276 (03) :1118-1128

[6] Modern science versus the stigma of obesity [J].

Friedman, JM .

NATURE MEDICINE, 2004, 10 (06) :563-569

[7] Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle [J].

Frigeri, A ;

Nicchia, GP ;

Verbavatz, JM ;

Valenti, G ;

Svelto, M .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (04) :695-703

[8] Altered aquaporin-4 expression in human muscular dystrophies: a common feature? [J].

Frigeri, A ;

Nicchia, GP ;

Repetto, S ;

Bado, M ;

Minetti, C ;

Svelto, M .

FASEB JOURNAL, 2002, 16 (07) :1120-+

[9] Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx mice [J].

Frigeri, A ;

Nicchia, GP ;

Nico, B ;

Quondamatteo, F ;

Herken, R ;

Roncali, L ;

Svelto, M .

FASEB JOURNAL, 2001, 15 (01) :90-98

[10] CONTRIBUTION OF INTRAABDOMINAL FAT ACCUMULATION TO THE IMPAIRMENT OF GLUCOSE AND LIPID-METABOLISM IN HUMAN OBESITY [J].

FUJIOKA, S ;

MATSUZAWA, Y ;

TOKUNAGA, K ;

TARUI, S .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1987, 36 (01) :54-59

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