The inflammatory response in cerebral ischemia: Focus on cytokines in stroke patients

被引：27

作者：

De Simoni, MG

Milia, P

Barba, M

De Luigi, A

Parnetti, L

Gallai, V

机构：

[1] Mario Negri Inst Pharmacol Res, Lab Inflammat & Nervous Syst Dis, Dept Neurosci, I-20157 Milan, Italy

[2] Univ Perugia, Dept Neurosci, Stroke Unit, I-06100 Perugia, Italy

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2002年 / 24卷 / 7-8期

关键词：

cytochines; inflammation; peripheral markers;

D O I：

10.1081/CEH-120015330

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper outlines the characteristics of the inflammatory reaction to brain ischemia with the aim of underlying its relevance and specific implication in the pathogenesis of this disorder. The attention is focused on cytokines, major inflammatory mediators produced in the central nervous system and in the periphery in the context of the response to brain injury. The available data on cytokines in patients with stroke are reviewed to investigate the characteristics of the inflammatory response in human samples and to elucidate if the production of these inflammatory molecules may be related to the clinical outcome.

引用

收藏

页码：535 / 542

页数：8

相关论文

共 27 条

[1] Inflammatory mediators and stroke: New opportunities for novel therapeutics [J].

Barone, FC ;

Feuerstein, GZ .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (08) :819-834

[2] INTERLEUKIN-6 AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN ACUTE STROKE [J].

BEAMER, NB ;

COULL, BM ;

CLARK, WM ;

HAZEL, JS ;

SILBERGER, JR .

ANNALS OF NEUROLOGY, 1995, 37 (06) :800-805

[3] Proinflammatory cytokines, measured in a mixed population on arrival in the emergency department, are related to mortality and severity of disease [J].

Carlstedt, F ;

Lind, L ;

Lindahl, B .

JOURNAL OF INTERNAL MEDICINE, 1997, 242 (05) :361-365

[4] The sympathetic nervous system tonically inhibits peripheral interleukin-1β and interleukin-6 induction by central lipopolysaccharide [J].

De Luigi, A ;

Terreni, L ;

Sironi, M ;

De Simoni, MG .

NEUROSCIENCE, 1998, 83 (04) :1245-1250

[5]

De Simoni MG, 1997, NEUROSCI RES COMMUN, V21, P163

[6] CENTRAL ENDOTOXIN INDUCES DIFFERENT PATTERNS OF INTERLEUKIN (IL)-1-BETA AND IL-6 MESSENGER-RIBONUCLEIC-ACID EXPRESSION AND IL-6 SECRETION IN THE BRAIN AND PERIPHERY [J].

DESIMONI, MG ;

DELBO, R ;

DELUIGI, A ;

SIMARD, S ;

FORLONI, G .

ENDOCRINOLOGY, 1995, 136 (03) :897-902

[7] MODULATION OF SYSTEMIC INTERLEUKIN-6 INDUCTION BY CENTRAL INTERLEUKIN-1 [J].

DESIMONI, MG ;

DELUIGI, A ;

GEMMA, L ;

SIRONI, M ;

MANFRIDI, A ;

GHEZZI, P .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (04) :R739-R742

[8] INTRACEREBROVENTRICULAR INJECTION OF INTERLEUKIN-1 INDUCES HIGH CIRCULATING LEVELS OF INTERLEUKIN-6 [J].

DESIMONI, MG ;

SIRONI, M ;

DELUIGI, A ;

MANFRIDI, A ;

MANTOVANI, A ;

GHEZZI, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (05) :1773-1778

[9] Pathobiology of ischaemic stroke: an integrated view [J].

Dirnagl, U ;

Iadecola, C ;

Moskowitz, MA .

TRENDS IN NEUROSCIENCES, 1999, 22 (09) :391-397

[10]

Elkarim RA, 1998, EUR J CLIN INVEST, V28, P295