Viral persistence in vivo through selection of neutralizing antibody-escape variants

被引:113
作者
Ciurea, A [1 ]
Klenerman, P [1 ]
Hunziker, L [1 ]
Horvath, E [1 ]
Senn, BM [1 ]
Ochsenbein, AF [1 ]
Hengartner, H [1 ]
Zinkernagel, RM [1 ]
机构
[1] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
基金
英国惠康基金;
关键词
D O I
10.1073/pnas.040558797
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Despite initial virus control by CD8(+) cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections. The role of neutralizing antibodies (nAbs) in controlling disease progression is unclear. Therefore, the phenomenon of viral evasion from the nAb response and its implications for virus persistence remain controversial. Here we demonstrate nab-mediated viral clearance in CTL-deficient mice infected with the prototypic noncytopathic lymphocytic choriomeningitis virus (strain WE). During prolonged CTL absence, neutralization-resistant virus mutants were selected in individual mice within 70-90 days. In naive animals infected with these virus variants only low nAb responses were induced, resulting in an increased tendency of virus to persist.
引用
收藏
页码:2749 / 2754
页数:6
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