Monocyte chemoattractant protein-1 in acute coronary syndromes: Complex vicious interaction

被引：15

作者：

Amasyali, Basri ^{[2
]}

Kose, Sedat

Kursaklioglu, Hurkan

Barcin, Cem

Kilic, Ayhan ^{[1
]}

机构：

[1] Gulhane Mil Med Acad, Dept Pediat Cardiol, TR-06018 Etlik, Turkey

[2] Gulhane Mil Med Acad, Dept Cardiol, Gulhane Mil Med Sch, TR-06018 Etlik, Turkey

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 136卷 / 03期

关键词：

Monocyte chemoattractant protein-1; Cytokine; Acute coronary syndromes; ATHEROSCLEROSIS; MCP-1; MICE;

D O I：

10.1016/j.ijcard.2008.04.080

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monocyte chemoattractant protein-1 (MCP-1) plays a crucial role both in the initiation and progression of atherosclerosis. MCP-1 is a unique cytokine produced by macrophages, smooth muscle cells and endothelial cells within atherosclerotic plaques and seems to be a reliable indicator of atherosclerotic plaque burden. Higher levels of MCP-1 have been associated with a poor prognosis and increased risk for death independent of other risk factors in patients with acute coronary syndromes. In this paper, we discussed the role of MCP-1 in the pathogenesis of acute coronary syndromes. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：356 / 357

页数：2

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