Resveratrol inhibits MMP-9 expression by up-regulating PPAR α expression in an oxygen glucose deprivation-exposed neuron model

被引：56

作者：

Cheng, Gang ^{[1
]}

Zhang, Xiang ^{[1
]}

Gao, Dakuan ^{[1
]}

Jiang, Xiaofan ^{[1
]}

Dong, Wenpeng ^{[2
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Inst Neurosurg, Xian 710032, Shaanxi Prov, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Gastrointestinal Surg, Xian 710032, Shaanxi Prov, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2009年 / 451卷 / 02期

关键词：

Resveratrol; Peroxisome proliferators-activated receptor; Matrix metalloproteinase; Oxygen glucose deprivation; ACTIVATED RECEPTOR-ALPHA; MATRIX-METALLOPROTEINASE INHIBITOR; CEREBRAL-ISCHEMIA; LIGAND-BINDING; FOCAL ISCHEMIA; BRAIN-DAMAGE; GAMMA; PROTEIN; STROKE; FENOFIBRATE;

D O I：

10.1016/j.neulet.2008.12.045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Resveratrol (trans-3,4',5-trihydroxystilbene, Res) is a natural polyphenol. A recent experiment confirmed that Res can selectively activate both peroxisome proliferators-activated receptors (PPAR) alpha and gamma. In addition, Res can protect neurons by matrix metalloproteinase-9 (MMP-9) down-regulation. The relationship between Res, MMP-9 and PPAR alpha or gamma was studied in an oxygen glucose deprivation-exposed neuron model. It showed that Res can inhibit mRNA and protein expression of MMP-9, while it up-regulates the expression of PPAR alpha and gamma. The effect of Res on both PPAR alpha and MMP-9 can be offset partially by MK886. However, PPAR gamma antagonist GW9662 had little effect on MMP-9 expression. These results suggest that Res can inhibit MMP-9 expression by up-regulating PPAR alpha. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：105 / 108

页数：4

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