RNA seeing double: Close-packing of helices in RNA tertiary structure

被引：40

作者：

Strobel, SA

Doudna, JA

机构：

[1] Dept. Molec. Biophys. and Biochem., Yale University, New Haven, CT 06520

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(97)01056-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structured RNA molecules play essential roles in RNA processing, chromosome maintenance and protein biosynthesis. RNA necessarily uses different strategies than proteins for folding and assembly of complex architectures. The RNA-folding problem is largely an issue of helical packing: how does RNA organize and pack short, double-helical segments to produce active sites and recognition motifs for proteins? Noncanonical base pairs, metal ions and 2'-hydroxyl groups are key elements in RNA higher-order structure formation.

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页码：262 / 266

页数：5

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