Role of extracellular signal regulated kinases 1 and 2 in neuronal survival

被引:232
作者
Hetman, M
Gozdz, A
机构
[1] Univ Louisville, Kentucky Spinal Cord Res Injury Ctr, Louisville, KY 40292 USA
[2] Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USA
[3] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA
[4] M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 2004年 / 271卷 / 11期
关键词
apoptosis; MAP-kinase; neurons; neuroprotection; programmed cell death; signal transduction; survival;
D O I
10.1111/j.1432-1033.2004.04133.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Extracellular signal regulated kinases 1 and 2 (ERK1/2) regulate cellular responses to a variety of extracellular stimuli. In the nervous system, ERK1/2 is critical for neuronal differentiation, plasticity and may also modulate neuronal survival. In this minireview, we present evidence that supports prosurvival activity of ERK1/2 in neurons. Several reports suggest that ERK1/2 mediates neuroprotective activity of extracellular factors, including neurotrophins. In addition, ERK1/2 is activated by neuronal injury. In damaged cells, ERK1/2 activation may act as a defensive mechanism that helps to compensate for the deleterious effects of a damaging insult. The emerging mechanisms of ERK1/2-mediated neuroprotection may involve transcriptional regulation and/or direct inhibition of cell death machinery.
引用
收藏
页码:2050 / 2055
页数:6
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