Molecular mechanisms of liver development and differentiation

被引：73

作者：

Darlington, GJ

机构：

[1] Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(99)00035-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances in identifying molecular signals that dictate liver development and differentiation have come from analysis of several experimental systems including the developing embryo, cell and tissue culture, knockout mice and transplantation of hepatic precursor cells. Fibroblast growth factors and several families of transcription factors including hepatocyte nuclear factors 1, 3 and 4 and CCAAT/enhancer-binding protein have been shown to be important components of the differentiation process that culminates in the fully functional liver.

引用

收藏

页码：678 / 682

页数：5

相关论文

共 32 条

[1] Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes [J].

Amicone, L ;

Spagnoli, FM ;

Spath, G ;

Giordano, S ;

Tommasini, C ;

Bernardini, S ;

DeLuca, V ;

DellaRocca, C ;

Weiss, MC ;

Comoglio, PM ;

Tripodi, M .

EMBO JOURNAL, 1997, 16 (03) :495-503

[2] HNF-3-BETA IS ESSENTIAL FOR NODE AND NOTOCHORD FORMATION IN MOUSE DEVELOPMENT [J].

ANG, SL ;

ROSSANT, J .

CELL, 1994, 78 (04) :561-574

[3] CELL CELL AND CELL MATRIX INTERACTIONS DIFFERENTIALLY REGULATE THE EXPRESSION OF HEPATIC AND CYTOSKELETAL GENES IN PRIMARY CULTURES OF RAT HEPATOCYTES [J].

BENZEEV, A ;

ROBINSON, GS ;

BUCHER, NLR ;

FARMER, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) :2161-2165

[4]

Bossard P, 1998, DEVELOPMENT, V125, P4909

[5] GENETIC-ANALYSIS OF A TRANSCRIPTIONAL ACTIVATION PATHWAY BY USING HEPATOMA-CELL VARIANTS [J].

BULLA, GA ;

FOURNIER, REK .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (11) :7086-7094

[6]

BURGESSBEUSSE B, 1998, LIVER GROWTH REGENER, P143

[7] Liver-enriched transcription factors and hepatocyte differentiation [J].

Cereghini, S .

FASEB JOURNAL, 1996, 10 (02) :267-282

[8] DISRUPTION OF THE HNF-4 GENE, EXPRESSED IN VISCERAL ENDODERM, LEADS TO CELL-DEATH IN EMBRYONIC ECTODERM AND IMPAIRED GASTRULATION OF MOUSE EMBRYOS [J].

CHEN, WS ;

MANOVA, K ;

WEINSTEIN, DC ;

DUNCAN, SA ;

PLUMP, AS ;

PREZIOSO, VR ;

BACHVAROVA, RF ;

DARNELL, JE .

GENES & DEVELOPMENT, 1994, 8 (20) :2466-2477

[9] Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth [J].

Croniger, C ;

Trus, M ;

LysekStupp, K ;

Cohen, H ;

Liu, Y ;

Darlington, GJ ;

Poli, V ;

Hanson, RW ;

Reshef, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (42) :26306-26312

[10] C/EBP and the control of phosphoenolpyruvate carboxykinase gene transcription in the liver [J].

Croniger, C ;

Leahy, P ;

Reshef, L ;

Hanson, RW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (48) :31629-31632

← 1 2 3 4 →