Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos

被引：96

作者：

Kume, S

Muto, A

Inoue, T

Suga, K

Okano, H

Mikoshiba, K

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT MOL NEUROBIOL,MINATO KU,TOKYO 108,JAPAN

[2] OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT NEUROANAT,SUITA,OSAKA 565,JAPAN

[3] CORE RES EVOLUT SCI & TECHNOL,JST,SUITA,OSAKA 565,JAPAN

[4] RIKEN,BRAIN SCI INST,WAKO,SAITAMA 35101,JAPAN

来源：

SCIENCE | 1997年 / 278卷 / 5345期

关键词：

D O I：

10.1126/science.278.5345.1940

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.

引用

页码：1940 / 1943

页数：4

共 44 条

[1] MESODERMAL INDUCTION IN EARLY AMPHIBIAN EMBRYOS BY ACTIVIN-A (ERYTHROID-DIFFERENTIATION FACTOR) [J].