A role for CD81 in early T cell development

被引：93

作者：

Boismenu, R

Rhein, M

Fischer, WH

Havran, WL

机构：

[1] Scripps Res Inst, DEPT IMMUNOL, LA JOLLA, CA 92037 USA

[2] SALK INST BIOL STUDIES, CLAYTON FDN LABS PEPTIDE BIOL, LA JOLLA, CA 92037 USA

来源：

SCIENCE | 1996年 / 271卷 / 5246期

关键词：

D O I：

10.1126/science.271.5246.198

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Early stages of T cell development are thought to include a series of coordinated interactions between thymocytes and other cells of the thymus. A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of alpha beta but nor gamma delta T cells in fetal organ cultures initiated with day 14.5 thymus lobes. In reaggregation cultures with CD81-transfected fibroblasts, CD4(-)CD8(-) thymocytes differentiated into CD4(+)CD8(+) T cells, Thus, interactions between immature thymocytes and stromal cells expressing CD81 are required and may be sufficient to induce early events associated with T cell development.

引用

页码：198 / 200

页数：3

共 26 条

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[2]

Alschul S F, 1990, J Mol Biol, V215, P403

[3] MHC CLASS-II-POSITIVE EPITHELIUM AND MESENCHYME CELLS ARE BOTH REQUIRED FOR T-CELL DEVELOPMENT IN THE THYMUS [J].