Lipoprotein lipase, a key role in atherosclerosis?

被引：57

作者：

Mead, JR ^{[1
]}

Cryer, A ^{[1
]}

Ramji, DP ^{[1
]}

机构：

[1] Cardiff Univ, Sch Biosci, Cardiff CF1 3US, S Glam, Wales

来源：

FEBS LETTERS | 1999年 / 462卷 / 1-2期

基金：

英国惠康基金;

关键词：

lipoprotein lipase; atherosclerosis; macrophage; foam cell; cytokine;

D O I：

10.1016/S0014-5793(99)01495-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipoprotein lipase (LPL) plays a central role in lipid metabolism and transport by catalysing the hydrolysis of triacylglycerol-rich lipoproteins. The importance of LPL expressed by the adipose tissue and muscles in the provision of non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation is well established, However, recent studies on LPL expressed by cells of the vascular wall, particularly macrophages, have identified additional actions of the enzyme that contribute to the promotion of foam cell formation and atherosclerosis, This review deals with the role of LPL in atherosclerosis, and its regulation by mediators that are known to be present in the lesion. (C) 1999 Federation of European Biochemical Societies.

引用

页码：1 / 6

页数：6

共 92 条

[1] Reactive oxygen species as mediators of signal transduction in cardiovascular disease [J].

Abe, J ;

Berk, BC .

TRENDS IN CARDIOVASCULAR MEDICINE, 1998, 8 (02) :59-64

[2]

Auerbach BJ, 1999, ATHEROSCLEROSIS, V142, P89

[3] Oxidation of low density lipoproteins greatly enhances their association with lipoprotein lipase anchored to endothelial cell matrix [J].

Auerbach, BJ ;

Bisgaier, CL ;

Wolle, J ;

Saxena, U .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1329-1335

[4]

AVIRAM M, 1988, J BIOL CHEM, V263, P15416

[5] Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo [J].

Babaev, VR ;

Fazio, S ;

Gleaves, LA ;

Carter, KJ ;

Semenkovich, CF ;

Linton, MF .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (12) :1697-1705

[6] RECEPTORS FOR TRIGLYCERIDE-RICH LIPOPROTEINS AND THEIR ROLE IN LIPOPROTEIN METABOLISM [J].

BEISIEGEL, U .

CURRENT OPINION IN LIPIDOLOGY, 1995, 6 (03) :117-122

[7] LIPOPROTEIN-LIPASE ENHANCES THE BINDING OF CHYLOMICRONS TO LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN [J].

BEISIEGEL, U ;

WEBER, W ;

BENGTSSONOLIVECRONA, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8342-8346

[8] Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene [J].

Benlian, P ;

DeGennes, JL ;

Foubert, L ;

Zhang, HF ;

Gagne, SE ;

Hayden, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (12) :848-854

[9] REGULATION OF THE SYNTHESIS, PROCESSING AND TRANSLOCATION OF LIPOPROTEIN-LIPASE [J].

BRAUN, JEA ;

SEVERSON, DL .

BIOCHEMICAL JOURNAL, 1992, 287 :337-347

[10] LIPOPROTEIN METABOLISM IN THE MACROPHAGE - IMPLICATIONS FOR CHOLESTEROL DEPOSITION IN ATHEROSCLEROSIS [J].

BROWN, MS ;

GOLDSTEIN, JL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :223-261

← 1 2 3 4 5 6 7 8 9 10 →