Farnesyltransferase inhibitors: promises and realities

被引：118

作者：

Cox, AD

Der, CJ

机构：

[1] Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1471-4892(02)00181-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Farnesyltransferase inhibitors have recently shown clinical efficacy against leukemias, gliomas and even non-small-cell lung cancers, especially when administered in combination with taxanes. It is possible that the critical target downstream of farnesyltransferase responsible for these effects is not either Ras or RhoB, the two most cited possibilities-but the hunt is on.

引用

页码：388 / 393

页数：6

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