Tumour necrosis factor and cancer

被引：1496

作者：

Balkwill, Frances ^{[1
]}

机构：

[1] Queen Mary Univ London, Ctr Canc & Inflammat, Inst Canc, Barts & London Sch Med & Dent, London EC1M 6BQ, England

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 05期

基金：

英国医学研究理事会;

关键词：

ISOLATED LIMB PERFUSION; NF-KAPPA-B; FACTOR-ALPHA INHIBITOR; HUMAN OVARIAN-CANCER; TNF FAMILY LIGANDS; RECOMBINANT HUMAN; MOLECULAR-CLONING; FACTOR-RECEPTOR; PHASE-I; HUMAN LYMPHOTOXIN;

D O I：

10.1038/nrc2628

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to harness this anti-tumour activity in cancer treatments were underway, a paradoxical tumour-promoting role of TNF became apparent. Now that links between inflammation and cancer are appreciated, is TNF a target or a therapeutic in malignant disease - or both?

引用

页码：361 / 371

页数：11

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