Adipose Tissue: A Motor for the Inflammation Associated with Obesity

被引：110

作者：

Vachharajani, Vidula ^{[2
]}

Granger, D. Neil ^{[1
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Mol & Cellular Physiol, Shreveport, LA 71130 USA

[2] Wake Forest Univ, Sch Med, Dept Anesthesiol, Winston Salem, NC 27109 USA

来源：

IUBMB LIFE | 2009年 / 61卷 / 04期

关键词：

adipokines; microcirculation; oxidative stress; immune cells; adhesion molecules; leukocytes; platelets; insulin resistance; endothelial cells; MICROVASCULAR DYSFUNCTION; CELL; FAT; RESISTIN; LEPTIN; DEFICIENCY; RESPONSES; ISCHEMIA; ADHESION; STROKE;

D O I：

10.1002/iub.169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is a worldwide epidemic that continues to grow at an alarming rate. This condition increases the morbidity and mortality associated with both acute and chronic diseases. Some of the deleterious consequences of obesity have been attributed to its induction of a low-grade chronic inflammatory state that arises from the production and secretion of inflammatory mediators from the expanded pool of activated adipocytes. This review focuses on the mechanisms that underlie the proposed link between obesity and inflammation, and it addresses how obesity-induced inflammation may account for increased morbidity and mortality that is associated with a diverse group of diseases. (C) 2009 IUBMB

引用

页码：424 / 430

页数：7

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