Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

被引：261

作者：

Duda, JE

Giasson, BI

Mabon, ME

Lee, VMY

Trojanowski, JQ

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[2] Philadelphia Vet Affairs Hosp, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA USA

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 02期

关键词：

D O I：

10.1002/ana.10279

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.

引用

页码：205 / 210

页数：6

共 28 条

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