The HIF pathway as a therapeutic target

被引：135

作者：

Hewitson, KS

Schofield, CJ

机构：

[1] Oxford Ctr Mol Sci, Oxford OX1 3TA, England

[2] Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

DRUG DISCOVERY TODAY | 2004年 / 9卷 / 16期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S1359-6446(04)03202-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypoxia-inducible factor (HIF) is an alpha,beta-heterodimeric transcription factor that mediates cellular responses to low oxygen concentration via the transcriptional activation of specific genes involved in both tumorogenesis and angiogenesis. Manipulation of the HIF pathway has potential use for the treatment of ischemic disease and cancer. Unlike HIF-beta, which is constitutively expressed, the levels and activity of the HIF-alpha subunit are regulated by processes involving posttranslational hydroxylation, catalyzed by Fe(II)- and 2-oxoglutarate-dependent oxygenases. This review focuses on the HIF pathway as a therapeutic target.

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页码：704 / 711

页数：8

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