Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

被引：655

作者：

Fazeli, A

Dickinson, SL

Hermiston, ML

Tighe, RV

Steen, RG

Small, CG

Stoeckli, ET

KeinoMasu, K

Masu, M

Rayburn, H

Simons, J

Bronson, RT

Gordon, JI

TessierLavigne, M

Weinberg, RA

机构：

[1] MIT,WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[2] MIT,DEPT BIOL,CAMBRIDGE,MA 02142

[3] WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL,ST LOUIS,MO 63110

[4] MIT,WHITEHEAD INST GENOME CTR,CAMBRIDGE,MA 02142

[5] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143

[6] UNIV CALIF SAN FRANCISCO,DEPT ANAT,CELL BIOL PROGRAM,SAN FRANCISCO,CA 94143

[7] UNIV CALIF SAN FRANCISCO,DEPT ANAT,PROGRAM DEV BIOL & NEUROSCI,SAN FRANCISCO,CA 94143

[8] NATL DEF MED COLL,DEPT PHYSIOL,TOKOROZAWA,SAITAMA 359,JAPAN

[9] MIT,CTR CANC RES,CAMBRIDGE,MA 02139

[10] JOHNS HOPKINS UNIV,JAMES BUCHANAN BRADY UROL INST,BALTIMORE,MD 21207

[11] TUFTS UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02111

[12] TUFTS UNIV,SCH VET MED,DEPT PATHOL,BOSTON,MA 02111

来源：

NATURE | 1997年 / 386卷 / 6627期

关键词：

D O I：

10.1038/386796a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies In rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC Is a component of a receptor for netrin-1.

引用

页码：796 / 804

页数：9

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[1] MICROALLELOTYPING DEFINES THE SEQUENCE AND TEMPO OF ALLELIC LOSSES AT TUMOR-SUPPRESSOR GENE LOCI DURING COLORECTAL-CANCER PROGRESSION [J].