Hijacking the translation apparatus by RNA viruses

被引：149

作者：

Bushell, M ^{[1
]}

Sarnow, P ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

JOURNAL OF CELL BIOLOGY | 2002年 / 158卷 / 03期

基金：

英国惠康基金;

关键词：

translation; picornavirus; rotavirus; cricket paralysis-like virus; start codon selection;

D O I：

10.1083/jcb.200205044

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As invading viruses do not harbor functional ribosomes in their virions, successful amplification of the viral genomes requires that viral mRNAs compete with cellular mRNAs for the host cell translation apparatus. Several RNA viruses have evolved remarkable strategies to recruit the host translation initiation factors required for the first steps in translation initiation by host cell mRNAs. This review describes the ways that three families of RNA viruses effectively usurp limiting translation initiation factors from the host.

引用

页码：395 / 399

页数：5

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