Peptides in membranes: Tipping the balance of membrane stability

被引：130

作者：

Brasseur, R

Pillot, T

Lins, L

Vandekerckhove, J

Rosseneu, M

机构：

[1] STATE UNIV GHENT, LAB LIPOPROT CHEM, DEPT BIOCHEM, B-9000 GHENT, BELGIUM

[2] STATE UNIV GHENT VIB, DEPT BIOCHEM, FAC MED, B-9000 GHENT, BELGIUM

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(97)01047-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes a class of peptides that associate with lipids in membranes and are commonly known as 'oblique-orientated peptides'. Owing to an asymmetric distribution of hydrophobic residues along the axis of the alpha-helix, such peptides can destabilize membranes or lipid cores, thereby facilitating such cellular processes as vesicular fusion or protein transport across subcellular compartments, as well as remodelling of lipid cores.

引用

页码：167 / 171

页数：5

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