The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm

被引:174
作者
Dandona, P
Aljada, A
Mohanty, P
机构
[1] SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA
[2] Kaleida Hlth, Buffalo, NY USA
关键词
D O I
10.1007/s00125-001-0766-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:924 / 930
页数:7
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共 80 条
[1]  
ALESSI MC, 1988, THROMB HAEMOSTASIS, V60, P491
[2]   Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations [J].
Aljada, A ;
Ghanim, H ;
Mohanty, P ;
Kapur, N ;
Dandona, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (03) :1419-1422
[3]   Increased IκB expression and diminished nuclear NF-κB in human mononuclear cells following hydrocortisone injection [J].
Aljada, A ;
Ghanim, H ;
Assian, E ;
Mohanty, P ;
Hamouda, W ;
Garg, R ;
Dandona, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (09) :3386-3389
[4]   Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide [J].
Aljada, A ;
Saadeh, R ;
Assian, E ;
Ghanim, H ;
Dandona, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (07) :2572-2575
[5]   Effect of insulin on human aortic endothelial nitric oxide synthase [J].
Aljada, A ;
Dandona, P .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2000, 49 (02) :147-150
[6]   Tumor necrosis factor-α inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells [J].
Aljada, A ;
Ghanim, H ;
Assian, E ;
Dandona, P .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2002, 51 (04) :487-491
[7]   Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) [J].
Aljada, A ;
Ghanim, H ;
Mohanty, P ;
Hofmeyer, D ;
Tripathy, D ;
Dandona, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (12) :5988-5991
[8]   Nuclear factor-κB suppressive and inhibitor-κB stimulatory effects of troglitazone in obese patients with type 2 diabetes:: Evidence of an antiinflammatory action? [J].
Aljada, A ;
Garg, R ;
Ghanim, H ;
Mohanty, P ;
Hamouda, W ;
Assian, E ;
Dandona, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (07) :3250-3256
[9]  
Aljada A, 2001, DIABETES, V50, pA532
[10]   Insulin inhibits NFκB and MCP-1 expression in human aortic endothelial cells [J].
Aljada, A ;
Ghanim, H ;
Saadeh, R ;
Dandona, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (01) :450-453