Localization of Xenopus Vg1 mRNA by vera protein and the endoplasmic reticulum

被引：232

作者：

Deshler, JO ^{[1
]}

Highett, MI ^{[1
]}

Schnapp, BJ ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, DEPT CELL BIOL, BOSTON, MA 02115 USA

来源：

SCIENCE | 1997年 / 276卷 / 5315期

关键词：

D O I：

10.1126/science.276.5315.1128

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg, in Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.

引用

页码：1128 / 1131

页数：4

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