MMDB: 3D structure data in Entrez

被引:33
作者
Wang, YL [1 ]
Addess, KJ [1 ]
Geer, L [1 ]
Madej, T [1 ]
Marchler-Bauer, A [1 ]
Zimmerman, D [1 ]
Bryant, SH [1 ]
机构
[1] NIH, Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA
关键词
D O I
10.1093/nar/28.1.243
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Three-dimensional structures are now known for roughly half of all protein families. It is thus quite likely, in searching sequence databases, that one will encounter a homolog with known structure and be able to use this information to infer structure-function properties. The goal of Entrez's 3D structure database is to make this information accessible and useful to molecular biologists, To this end, Entrez's search engine provides three powerful features: (i) Links between databases; one may search by term matching in Medline(R), for example, and link to 3D structures reported in these articles, (ii) Sequence and structure neighbors; one may select all sequences similar to one of interest, for example, and link to any known 3D structures, (iii) Sequence and structure visualization; identifying a homolog with known structure, one may view a combined molecular-graphic and alignment display, to infer approximate 3D structure. Entrez's MMDB (Molecular Modeling DataBase) may be accessed at: http://www.ncbi.nlm.nih.gov/Entrez/structure.html.
引用
收藏
页码:243 / 245
页数:3
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