Assessment of homocysteine status

被引：75

作者：

Refsum, H

Fiskerstrand, T

Guttormsen, AB

Ueland, PM

机构：

来源：

JOURNAL OF INHERITED METABOLIC DISEASE | 1997年 / 20卷 / 02期

关键词：

D O I：

10.1023/A:1005321225893

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In the present article, we review basic knowledge for a rational use of plasma tHcy in diagnostic as well as scientific work. The subjects dealt with are procedures for sample handling and processing, the principles of tHcy analyses, and genetic and acquired determinants of the plasma tHcy concentration.

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页码：286 / 294

页数：9

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