Clinical and electrophysiological features in Chinese patients with Kennedy's disease

被引：7

作者：

Hui, ACF ^{[1
]}

Cheung, PT

Tang, ASY

Fu, M

Wong, L

Kay, R

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Queen Mary Hosp, Dept Paediat, Hong Kong, Hong Kong, Peoples R China

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2004年 / 106卷 / 04期

关键词：

Kennedy's disease; genetics; trinucleotide repeats; electrophysiology;

D O I：

10.1016/j.clineuro.2004.02.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Kennedy's disease is a X-linked neuromuscular disorder caused by an expanded trinucleotide repeat in the androgen receptor gene. To ascertain the clinical diagnosis of Kennedy's disease in a Chinese population, we used a rapid, accurate PCR-based sizing method for the CAG repeat allelotype. The clinical and electrophysiological features of affected patients are described. The CAG repeats ranged from 43 to 53 and were inversely correlated with the age of onset (r = -0.63; P < 0.005). (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：309 / 312

页数：4

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