The anaphase-promoting complex: Proteolysis in mitosis and beyond

被引：761

作者：

Peters, JM ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

MOLECULAR CELL | 2002年 / 9卷 / 05期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S1097-2765(02)00540-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.

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收藏

页码：931 / 943

页数：13

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