A quantitative near-infrared spectroscopy study: A decrease in cerebral hemoglobin oxygenation in Alzheimer's disease and mild cognitive impairment

被引：91

作者：

Arai, Heii

Takano, Maki

Miyakawa, Koichi

Ota, Tsuneyoshi

Takahashi, Tadashi

Asaka, Hiroka'zu

Kawaguchi, Tsuneaki

机构：

[1] Juntendo Univ, Sch Med, Dept Psychiat, Bunkyo Ku, Tokyo 1130033, Japan

[2] Hitachi Med Corp, Kashiwa, Chiba 2770804, Japan

来源：

BRAIN AND COGNITION | 2006年 / 61卷 / 02期

关键词：

near-infrared spectroscopy; Alzheimer's disease; mild cognitive impairment; hemoglobin oxygenation; quantitative method; primary screening;

D O I：

10.1016/j.bandc.2005.12.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A newly developed quantitative near-infrared spectroscopy (NIRS) system was used to measure changes in cortical hemoglobin oxygenation during the Verbal Fluency Task in 32 healthy controls, 15 subjects with mild cognitive impairment (MCI), and 15 patients with Alzheimer's disease (AD). The amplitude of changes in the waveform, which was quantitatively calculated by a signal processing method, was significantly lower in the frontal, and the bilateral parietal areas in the AD group, whereas that in the MCI group was significantly lower only in the right parietal area. The NIRS system may be a potential tool for the primary screening of AD. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：189 / 194

页数：6

共 28 条

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