Meiotic chromosomes: Integrating structure and function

被引:1013
作者
Zickler, D [1 ]
Kleckner, N
机构
[1] Univ Paris Sud, Inst Genet & Microbiol, F-91405 Orsay, France
[2] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
关键词
D O I
10.1146/annurev.genet.33.1.603
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Meiotic chromosomes have been studied for many years, in part because of the fundamental life processes they represent, but also because meiosis involves the formation of homolog pairs, a feature which greatly facilitates the study of chromosome behavior. The complex events involved in homolog juxtaposition necessitate prolongation of prophase, thus permitting resolution of events that are temporally compressed in the mitotic cycle. Furthermore, once homologs are paired, the chromosomes are connected by a specific structure: the synaptonemal complex. Finally, interaction of homologs includes recombination at the DNA level, which is intimately linked to structural features of the chromosomes. In consequence, recombination-related events report on diverse aspects of chromosome morphogenesis, notably relationships between sisters, development of axial structure, and variations in chromatin status. The current article reviews recent information on these topics in an historical context. This juxtaposition has suggested new relationships between structure and function. Additional issues were addressed in a previous chapter (551).
引用
收藏
页码:603 / 754
页数:158
相关论文
共 570 条
[1]   SYNAPTONEMAL COMPLEX AND RECOMBINATION NODULES IN RYE (SECALE-CEREALE) [J].
ABIRACHED-DARMENCY, M ;
ZICKLER, D ;
CAUDERON, Y .
CHROMOSOMA, 1983, 88 (04) :299-306
[2]  
AJIMURA M, 1993, GENETICS, V133, P51
[3]  
Akhmanova A, 1997, MOL REPROD DEV, V48, P413, DOI 10.1002/(SICI)1098-2795(199712)48:4<413::AID-MRD1>3.3.CO
[4]  
2-W
[5]   ANALYSIS OF WILD-TYPE AND RAD50 MUTANTS OF YEAST SUGGESTS AN INTIMATE-RELATIONSHIP BETWEEN MEIOTIC CHROMOSOME SYNAPSIS AND RECOMBINATION [J].
ALANI, E ;
PADMORE, R ;
KLECKNER, N .
CELL, 1990, 61 (03) :419-436
[6]  
Albertson DG, 1997, C ELEGANS, P47
[7]   SYNAPTONEMAL COMPLEX SPREADING IN ALLIUM-CEPA AND ALLIUM-FISTULOSUM - .1. THE INITIATION AND SEQUENCE OF PAIRING [J].
ALBINI, SM ;
JONES, GH .
CHROMOSOMA, 1987, 95 (05) :324-338
[8]   SYNAPTONEMAL COMPLEX SPREADING IN ALLIUM-CEPA AND ALLIUM-FISTULOSUM .2. PACHYTENE OBSERVATIONS - THE SC KARYOTYPE AND THE CORRESPONDENCE OF LATE RECOMBINATION NODULES AND CHIASMATA [J].
ALBINI, SM ;
JONES, GH .
GENOME, 1988, 30 (03) :399-410
[9]  
Allen JW, 1996, CHROMOSOMA, V104, P414, DOI 10.1007/BF00352265
[10]   Architecture of the nuclear periphery of rat pachytene spermatocytes: Distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites [J].
Alsheimer, M ;
von Glasenapp, E ;
Hock, R ;
Benavente, R .
MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (04) :1235-1245