Exploring type I angiotensin (AT1) receptor functions through gene targeting

被引：44

作者：

Crowley, SD

Tharaux, PL

Audoly, LP

Coffman, TM

机构：

[1] Vet Adm Med Ctr, Durham, NC 27705 USA

[2] Duke Univ, Div Nephrol, Durham, NC USA

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 2004年 / 181卷 / 04期

关键词：

angiotensin II; AT(1) receptor; gene targeting; hypertension; renin-angiotensin system;

D O I：

10.1111/j.1365-201X.2004.01331.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The renin-angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT(1)) class of angiotensin receptors. Pharmacological blockade of the AT(1) receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene-targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene-targeting experiments have elucidated AT(1) receptor functions.

引用

收藏

页码：561 / 570

页数：10

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