Exosomes:: endosomal-derived vesicles shipping extracellular messages

被引：857

作者：

Février, B ^{[1
]}

Raposo, G ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 144, Res Sect, F-75005 Paris, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 04期

关键词：

D O I：

10.1016/j.ceb.2004.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosomes are membrane vesicles released into the extracellular environment upon exocytic fusion of multivesicular endosomes with the cell surface. They have a particular composition reflecting their origin in endosomes as intraluminal vesicles. In vitro and in vivo studies support the contribution of exosomes to an acellular mode of communication, leading to intercellular transfer of molecules. Exosomes may have regulatory functions in the immune system and their application in cancer immunotherapy is promising. The mechanisms involved in exosome secretion and interaction with target cells are as yet unclear. A better understanding of these mechanisms is also essential to determine the link between exosomes and retroviruses.

引用

页码：415 / 421

页数：7

共 62 条

[1] Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid [J].

Admyre, C ;

Grunewald, J ;

Thyberg, J ;

Gripenbäck, S ;

Tornling, G ;

Eklund, A ;

Scheynius, A ;

Gabrielsson, S .

EUROPEAN RESPIRATORY JOURNAL, 2003, 22 (04) :578-583

[2] Exosomes as potent cell-free peptide-based vaccine.: I.: Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells [J].

André, F ;

Chaput, N ;

Schartz, NEC ;

Flament, C ;

Aubert, N ;

Bernard, J ;

Lemonnier, F ;

Raposo, G ;

Escudier, B ;

Hsu, DH ;

Tursz, T ;

Amigorena, S ;

Angevin, E ;

Zitvogel, L .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2126-2136

[3] Malignant effusions and immunogenic tumour-derived exosomes [J].

Andre, F ;

Schartz, NEC ;

Movassagh, M ;

Flament, C ;

Pautier, P ;

Morice, P ;

Pomel, C ;

Lhomme, C ;

Escudier, B ;

Le Chevalier, T ;

Tursz, T ;

Amigorena, S ;

Raposo, G ;

Angevin, E ;

Zitvogel, L .

LANCET, 2002, 360 (9329) :295-305

[4]

BARD MP, 2004, AM J RESP CELL MOL B

[5] TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex [J].

Blanchard, N ;

Lankar, D ;

Faure, F ;

Regnault, A ;

Dumont, C ;

Raposo, G ;

Hivroz, C .

JOURNAL OF IMMUNOLOGY, 2002, 168 (07) :3235-3241

[6] Characteristics of human prostasomes isolated from three different sources [J].

Carlsson, L ;

Nilsson, O ;

Larsson, A ;

Stridsberg, M ;

Sahlén, G ;

Ronquist, G .

PROSTATE, 2003, 54 (04) :322-330

[7]

CHAPUT N, 2004, CANC IMMUNOL IMMUNOT

[8] Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts [J].

Claas, C ;

Stipp, CS ;

Hemler, ME .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) :7974-7984

[9] Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59 [J].

Clayton, A ;

Harris, CL ;

Court, J ;

Mason, MD ;

Morgan, BP .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (02) :522-531

[10] Lipid raft-associated protein sorting in exosomes [J].

de Gassart, A ;

Géminard, C ;

Février, B ;

Raposo, G ;

Vidal, M .

BLOOD, 2003, 102 (13) :4336-4344

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