Double indemnity: p53, BRCA and cancer

被引：105

作者：

Brugarolas, J

Jacks, T

机构：

[1] Howard Hughes Medical Institute MIT Center for Cancer Research,

来源：

NATURE MEDICINE | 1997年 / 3卷 / 07期

关键词：

D O I：

10.1038/nm0797-721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

引用

页码：721 / 722

页数：2

共 24 条

[1] A HUMAN BRCA1 GENE KNOCKOUT [J].

BOYD, M ;

HARRIS, F ;

MCFARLANE, R ;

DAVIDSON, HR ;

BLACK, DM .

NATURE, 1995, 375 (6532) :541-542

[2] RADIATION-INDUCED CELL-CYCLE ARREST COMPROMISED BY P21 DEFICIENCY [J].

BRUGAROLAS, J ;

CHANDRASEKARAN, C ;

GORDON, JI ;

BEACH, D ;

JACKS, T ;

HANNON, GJ .

NATURE, 1995, 377 (6549) :552-557

[3] THE CELLULAR-RESPONSES TO DNA-DAMAGE [J].

CARR, AM ;

HOEKSTRA, MF .

TRENDS IN CELL BIOLOGY, 1995, 5 (01) :32-40

[4] Transcriptional activation by BRCA1 [J].

Chapman, MS ;

Verma, IM .

NATURE, 1996, 382 (6593) :678-679

[5]

COENE E, 1997, NAT GENET, V16, P121

[6] MICE LACKING P21(C/P1/WAF1) UNDERGO NORMAL DEVELOPMENT, BUT ARE DEFECTIVE IN G1 CHECKPOINT CONTROL [J].

DENG, CX ;

ZHANG, PM ;

HARPER, JW ;

ELLEDGE, SJ ;

LEDER, P .

CELL, 1995, 82 (04) :675-684

[7] WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION [J].

ELDEIRY, WS ;

TOKINO, T ;

VELCULESCU, VE ;

LEVY, DB ;

PARSONS, R ;

TRENT, JM ;

LIN, D ;

MERCER, WE ;

KINZLER, KW ;

VOGELSTEIN, B .

CELL, 1993, 75 (04) :817-825

[8]

GLEBOV OK, 1994, CANCER RES, V54, P3703

[9] Partial rescue of Brca1(5-6) early embryonic lethality by p53 or p21 null mutation [J].

Hakem, R ;

delaPompa, JL ;

Eli, A ;

Potter, J ;

Mak, TW .

NATURE GENETICS, 1997, 16 (03) :298-302

[10] The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse [J].

Hakem, R ;

delaPompa, JL ;

Sirard, C ;

Mo, R ;

Woo, M ;

Hakem, A ;

Wakeham, A ;

Potter, J ;

Reitmair, A ;

Billia, F ;

Firpo, E ;

Hui, CC ;

Roberts, J ;

Rossant, J ;

Mak, TW .

CELL, 1996, 85 (07) :1009-1023

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