Do human RNA helicases have a role in cancer?

被引：82

作者：

Abdelhaleem, M ^{[1
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Paediat Lab, Div Haematopathol, Toronto, ON M5G 1X8, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2004年 / 1704卷 / 01期

关键词：

RNA helicase; cancer; RNA metabolism; transcription; splicing; translation; DDX and DHX;

D O I：

10.1016/j.bbcan.2004.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human RNA helicases (HRH) represent a large family of enzymes that play important roles in RNA processing. The biochemical characteristics and biological functions of the majority of HRH are still to be determined. However, there are examples of dysregulation of HRH expression in various types of cancer. In addition, some HRH have been shown to be involved in the regulation of, or the molecular interaction with, molecules implicated in cancer. Other helicases take part in fusion transcripts resulting from cancer-associated chromosomal translocation. These findings raise the question of whether HRH can contribute to cancer development/progression. In this review, I summarize the cancer-related features of HRH. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：37 / 46

页数：10

共 151 条

[1] The human DDX and DHX gene families of putative RNA helicases [J].