Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast

被引：113

作者：

Cheeseman, IM ^{[1
]}

Drubin, DG ^{[1
]}

Barnes, G ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

JOURNAL OF CELL BIOLOGY | 2002年 / 157卷 / 02期

关键词：

D O I：

10.1083/jcb.200201052

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation.

引用

页码：199 / 203

页数：5

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