Relationship among hyperinsulinemia, insulin resistance, and hypertension is dependent on sex

被引：42

作者：

Galipeau, DM ^{[1
]}

Yao, LF ^{[1
]}

McNeill, JH ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, Vancouver, BC V6T 1Z3, Canada

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2002年 / 283卷 / 02期

关键词：

blood pressure; insulin sensitivity; male; female; vasculature;

D O I：

10.1152/ajpheart.00238.2002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperinsulinemia and insulin resistance have been linked to hypertension; however, the influence of sex on this relationship has not been well studied. The purpose of this experiment was to compare the effects of chronic insulin treatment on insulin sensitivity and blood pressure in male and female rats. Male and female Wistar rats were treated with insulin (2 U/day) via subcutaneous sustained release implants for 5 wk. Systolic blood pressure was measured via the tail-cuff method before and after treatment, and insulin sensitivity was assessed with an oral glucose tolerance test. The insulin sensitivity of female rats was 4.5-fold greater than male rats. Chronic insulin treatment impaired insulin sensitivity in both sexes; however, this occurred to a greater degree in male rats. Blood pressure increased in male rats treated with insulin only. The results demonstrate that hyperinsulinemia and insulin resistance are associated with hypertension in male rats only. Therefore, the link between these conditions appears to depend on sex.

引用

页码：H562 / H567

页数：6

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