Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study

被引：32

作者：

Guasti, Luigina ^{[1
]}

Marino, Franca ^{[1
]}

Cosentino, Marco ^{[1
]}

Cimpanelli, Mariagrazia ^{[1
]}

Maio, Ramona C. ^{[1
]}

Klersy, Catherine ^{[1
]}

Crespi, Chiara ^{[1
]}

Restelli, Daniela ^{[1
]}

Simoni, Cinzia ^{[1
]}

Franzetti, Ivano ^{[1
]}

Gaudio, Giovanni ^{[1
]}

Marnini, Patrizio ^{[1
]}

Grandi, Anna M. ^{[1
]}

Lecchini, Sergio ^{[1
]}

Venco, Achille ^{[1
]}

机构：

[1] Univ Insubria, Dept Clin Med, I-21100 Varese, Italy

来源：

JOURNAL OF HYPERTENSION | 2006年 / 24卷 / 12期

关键词：

human polymorphonuclear leukocytes; interleukin-8; reactive; oxygen species; statins;

D O I：

10.1097/01.hjh.0000251903.62804.77

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Background Although extensive experimental evidence supports a primary role of polymorphonuclear leukocytes (PMNs) in atherosclerosis, few data exist concerning the functional properties of these cells and their pharmacological modulation in high-risk individuals. Objective The production of the proinflammatory chemokine interleukin-8 (IL-8), migration and chemotaxis, and reactive oxygen species (ROS) generation were investigated in a longitudinal study in PMNs obtained from high-risk individuals during statin treatment. As a secondary endpoint we compared PMN function of high-risk patients with that of controls. Methods and results PMNs were isolated from 21 high-risk individuals before treatment and 3 and 30 days after the beginning of simvastatin treatment, and from healthy controls. During treatment a significant reduction was observed both in resting (P = 0.009) and N-formyl-Met-Leu-Phe (fMLP)-stimulated (P = 0.008) IL-8 production, and in the chemotactic index (P = 0.038), whereas ROS generation did not significantly change. In comparison with cells from controls, PMNs obtained from patients before starting simvastatin treatment showed higher resting and fMLP-stimulated IL-8 release (P = 0.007 and P = 0.002, respectively) and ROS generation (resting, P = 0.009; and fMLP-stimulated, P = 0.046), whereas migration and the chemotactic index did not significantly differ. Conclusions An activation of neutrophils is present in high-risk individuals, shown by the enhanced production of IL-8, and increased ROS generation. The 4-week statin treatment is able to reduce the cell capability to produce IL-8, and to decrease chemotaxis, thus affecting the proinflammatory properties of PMNs.

引用

页码：2423 / 2430

页数：8

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