Evidence for autoregulation of cystathionine γ-synthase mRNA stability in Arabidopsis

被引:140
作者
Chiba, Y
Ishikawa, M
Kijima, F
Tyson, RH
Kim, J
Yamamoto, A
Nambara, E
Leustek, T
Wallsgrove, RM
Naito, S [1 ]
机构
[1] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Sapporo, Hokkaido 0608589, Japan
[2] AFRC, Inst Arable Crops Res, Dept Biochem & Physiol, Harpenden AL5 2JQ, Herts, England
[3] Rutgers State Univ, Biotechnol Ctr Agr & Environm, New Brunswick, NJ 08901 USA
关键词
D O I
10.1126/science.286.5443.1371
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Control of messenger RNA (mRNA) stability serves as an important mechanism, for regulating gene expression. Analysis of Arabidopsis mutants that overaccumulate soluble methionine (Met) revealed that the gene for cystathionine gamma-synthase (CCS), the key enzyme in Met biosynthesis, is regulated at the Level of mRNA stability, Transfection experiments with wild-type and mutant forms of the CCS gene suggest that an amino acid sequence encoded by the first exon of CCS acts in cis to destabilize its own mRNA in a process that is activated by Met or one of its metabolites.
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页码:1371 / 1374
页数:4
相关论文
共 31 条
[1]   MULTIPLE GLOBAL REGULATORS CONTROL HIS4 TRANSCRIPTION IN YEAST [J].
ARNDT, KT ;
STYLES, C ;
FINK, GR .
SCIENCE, 1987, 237 (4817) :874-880
[2]   ASSIGNMENT OF 30 MICROSATELLITE LOCI TO THE LINKAGE MAP OF ARABIDOPSIS [J].
BELL, CJ ;
ECKER, JR .
GENOMICS, 1994, 19 (01) :137-144
[3]  
CHIBA Y, UNPUB
[4]   SULFUR-CONTAINING-COMPOUNDS IN LEMNA PERPUSILLA 6746 GROWN AT A RANGE OF SULFATE CONCENTRATIONS [J].
DATKO, AH ;
MUDD, SH ;
GIOVANELLI, J ;
MACNICOL, PK .
PLANT PHYSIOLOGY, 1978, 62 (04) :629-635
[5]  
FUJIWARA T, 1991, PLANT CELL REP, V9, P602, DOI 10.1007/BF00231797
[6]  
GIOVANELLI J, 1990, SULFUR NUTRITION AND SULFUR ASSIMILATION IN HIGHER PLANTS, P33
[7]  
GUZMAN P, 1988, NUCLEIC ACIDS RES, V16, P11091, DOI 10.1093/nar/16.23.11091
[8]  
HIRAI MY, 1994, PLANT CELL PHYSIOL, V35, P927
[9]   ISOLATION OF AN ARABIDOPSIS-THALIANA MUTANT, MTO1, THAT OVERACCUMULATES SOLUBLE METHIONINE - TEMPORAL AND SPATIAL PATTERNS OF SOLUBLE METHIONINE ACCUMULATION [J].
INABA, K ;
FUJIWARA, T ;
HAYASHI, H ;
CHINO, M ;
KOMEDA, Y ;
NAITO, S .
PLANT PHYSIOLOGY, 1994, 104 (03) :881-887
[10]   EFFECTS OF THE TOM1 MUTATION OF ARABIDOPSIS-THALIANA ON THE MULTIPLICATION OF TOBACCO MOSAIC-VIRUS RNA IN PROTOPLASTS [J].
ISHIKAWA, M ;
NAITO, S ;
OHNO, T .
JOURNAL OF VIROLOGY, 1993, 67 (09) :5328-5338