The mammalian epigenome

被引：1591

作者：

Bernstein, Bradley E. ^{[1
]}

Meissner, Alexander

Lander, Eric S.

机构：

[1] Massachusetts Gen Hosp, Mol Pathol Unit, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Canc Res Ctr, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[4] Harvard Univ, Broad Inst, Cambridge, MA 02139 USA

[5] MIT, Cambridge, MA 02139 USA

[6] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02139 USA

来源：

CELL | 2007年 / 128卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.01.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment. With the sequencing of the human genome completed, investigators now seek a comprehensive view of the epigenetic changes that determine how genetic information is made manifest across an incredibly varied background of developmental stages, tissue types, and disease states. Here we review current research efforts, with an emphasis on large-scale studies, emerging technologies, and challenges ahead. © 2007 Elsevier Inc. All rights reserved.

引用

页码：669 / 681

页数：13

共 97 条

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